What Is The Most Important Determinant Of Toxicity?

What factors determine toxicity?

The toxicity of a substance usually depends on the following factors:Form and innate chemical activity.Dosage , especially dose -time relationship.Exposure route.Species.Life stage, such as infant, young adult, or elderly adult.Gender.Ability to be absorbed.Metabolism.More items….

What is the most common target organ of toxicity?

For example, the central nervous system may be the target organ for toxicity from a chemical after acute exposure whereas the liver may be affected after chronic exposures. Chemicals can cause many types of toxicity by a variety of mechanisms.

What is the basic principle of toxicology?

Evaluating clinical effects based on the amount of exposure is a basic toxicology principle called dose-response. The dose is the total amount of chemical absorbed during an exposure. Dose depends on the concentration of the chemical and duration (contact time) of the exposure.

What is chronic toxicity test?

Chronic toxicity tests are defined as tests that characterize adverse effects following repeated administration of a test substance over a significant portion of the life span of the test species. Establishing the duration of a chronic study is based on the anticipated human or environmental species’ exposure.

What is meant by chronic toxicity?

Chronic toxicity is defined as adverse effects occurring after the repeated or continuous administration of a test sample for a major part of the life span.

What is the importance of toxicology?

Toxicology provides critical information and knowledge that can be used by regulatory agencies, decision makers, and others to put programs and policies in place to limit our exposures to these substances, thereby preventing or reducing the likelihood that a disease or other negative health outcome would occur.

What five things does the toxicity of a drug or poison depend on?

When you inhale a toxic chemical, the dose you receive depends on four factors: (1) the level (concentration) of chemical in the air; (2) how hard (fast and deep) you are breathing, which depends on your degree of physical exertion; (3) how much of the chemical that is inhaled stays in your lungs and is absorbed into …

How do you test for toxicity?

The basic tool for determining toxicity of substances to marine and aquatic organisms is the toxicity test. In its simplest form, toxicity testing is taking healthy organisms from a container of clean water and placing into one containing the same water with a known concentration of a pollutant.

What is difference between acute and chronic toxicity?

Acute toxicity appears within hours or days of an exposure, whereas chronic toxicity takes many months or years to become a recognizable clinical disease.