Quick Answer: What Drugs Increase Warfarin Effect?

Does coffee affect warfarin?

It was concluded that caffeine has the capacity to inhibit the metabolism of warfarin and enhance its plasma concentration and hence anticoagulant effects.

Thus, patients should be advised to limit the frequent use of caffeine-rich products i.e.

tea and coffee during warfarin therapy..

Can Stress Affect INR levels?

The cases presented here demonstrate that stressful events, physical or psychological, can elevate the INR. The mechanism for this occurrence is unknown, but may be related to decreased metabolism of warfarin during stress.

What are major side effects of warfarin?

What are the side effects of warfarin?Severe bleeding, including heavier than normal menstrual bleeding.Red or brown urine.Black or bloody stool.Severe headache or stomach pain.Joint pain, discomfort or swelling, especially after an injury.Vomiting of blood or material that looks like coffee grounds.Coughing up blood.More items…•

How long can you live on warfarin?

As a general rule warfarin is prescribed to treat a blood clot for 3 – 6 months. For an irregular heart beat, recurrent blood clots or some heart valve problems, warfarin is prescribed indefinitely.

Can you eat oranges while taking warfarin?

Grapefruit, Seville or tangelo oranges and grapefruit juice Although these fruits and their juices are not high in vitamin K, they can affect how warfarin works in other ways. Avoid them unless your doctor or pharmacist says they are safe for you.

What drugs increase INR?

Drugs in this category include carbenicillin, allopurinol, erythromycin, indomethacin, ibuprofen, fluconazole, fenoprofen, isoniazid, ketoconazole, naproxen, metronidazole, phenylbutazone, moxalactam, cephalosporins, trimethoprim-sulfa (Bactrim), amiodarone, quinidine, cimetidine, clofibrate, lovastatin, omeprazole, …

Which drugs decrease the anticoagulant effects of warfarin?

Some drugs and herbal products that may reduce the anticoagulating effect of warfarin by increasing its breakdown include:St. John’s wort.carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol)rifampin, bosentan (Tracleer)prednisone.

Can you eat bananas while taking warfarin?

If you are a patient on warfarin, wondering whether it’s on your list of foods you can eat without worry shouldn’t make you crazy. The only time to be a little cautious when eating bananas is when you prepare green bananas.

Can aspirin increase INR?

An increased risk of bleeding is associated with both a more intense oral anticoagulation (i.e. a higher INR) and the use of aspirin [2–6]. It has also been demonstrated that a greater INR variability is an independent risk factor for major bleeding [7–9] in patients who are chronically anticoagulated.

What increases effects of warfarin?

John’s wort, and ginseng can decrease the effects of warfarin, thus increasing the risk of blood clots. Because high doses of vitamin A or vitamin E can increase the effect of anticoagulation, patients should only take the recommended daily doses based on instructions from their health care provider.

What causes INR to increase?

A high INR level can happen when you take warfarin (Coumadin). Warfarin helps prevent blood clots. To do this, it slows the amount of time it takes for your blood to clot. This raises your INR level.

How can I increase my INR level?

Certain foods and dietary supplements have vitamin K. Vitamin K works against warfarin. If you eat more vitamin K, it can decrease your INR. If you eat less vitamin K, it can increase your INR.

What foods cause INR to increase?

The foods that will potentially cause notable interactions with warfarin are mango, grapefruit, cranberry, and those with high vitamin K content such as certain green leafy vegetables, oils, multi-vitamins, herbal supplements, edible seaweed, avocado, and soymilk.

What does INR 1.5 mean?

An INR of 5.0 or higher means you’re at high risk of major bruising or bleeding. An INR of 1.5 or lower puts you at greater risk of developing a life-threatening blood clot.

Can high INR cause stroke?

People not taking warfarin have an INR of around 1 but patients with a mechanical heart valve should have an INR in the range of 2.5 to 3.5 to prevent their body creating a blood clot which could travel to the brain and cause a stroke.