Quick Answer: What Drug Class Is Aldosterone?

What type of hormone is aldosterone?

steroid hormoneAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa..

Is Spironolactone an aldosterone antagonist?

Spironolactone is a nonselective aldosterone antagonist, and eplerenone is selective to the aldosterone receptor. Although numerous clinical trials have evaluated the efficacy of each drug, no studies have directly compared spironolactone and eplerenone.

What hormone is antagonistic to aldosterone?

What hormone is antagonistic to the actions of aldosterone? How is the heart involved as an endocrine gland? A few cardiac cells secrete atrial natriuretic peptide (ANP), which helps regulate salt output by the kidney. ANP inhibits aldosterone and signals the kidney to remove more salt.

Can spironolactone make you gain weight?

There are concerns that spironolactone can cause weight gain, but there isn’t much evidence it does. For example, the package insert for the drug doesn’t list weight gain as a side effect. Along with weight gain, many people worry that spironolactone will make their skin look worse when they first start taking it.

Is there an alternative to spironolactone?

Amiloride and triamterene may be used instead of spironolactone. They have a direct effect on the renal tubule, impairing sodium reabsorption in exchange for potassium and hydrogen.

What class of drug is spironolactone?

Spironolactone is in a class of medications called aldosterone receptor antagonists. It causes the kidneys to eliminate unneeded water and sodium from the body into the urine but reduces the loss of potassium from the body.

What is the main function of aldosterone?

Aldosterone is a steroid hormone. Its main role is to regulate salt and water in the body, thus having an effect on blood pressure.

Does stress increase aldosterone?

Psychological stress also activates the sympathetic-adrenomedullary system which stimulates rennin release leading to increases in angiotensin II and aldosterone secretion. Aldosterone activates MR which in turn may lead to vascular injury and inflammation, and ultimately heart disease, renal disease, and stroke.

Does aldosterone make you pee?

Too much aldosterone makes the kidneys hang on to sodium and water and flush potassium into the urine. The extra fluid ends up in the bloodstream.

What are the long term side effects of spironolactone?

30 The most common side effects were diuretic effects (29%), menstrual irregularities (22%), and breast tenderness (17%). 30 The authors concluded that long-term use of spironolactone in the treatment of AV appears to be safe.

Is aldosterone a diuretic?

Because it’s a diuretic, this medication can affect your routine. If you take an aldosterone antagonist: Your kidneys will make more urine.

What should you not take with spironolactone?

What should I avoid while taking spironolactone? Drinking alcohol can increase certain side effects of spironolactone. Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking spironolactone.

Does aldosterone increase or decrease urine output?

Interestingly, the increased urine production in response to aldosterone was associated with significantly decreased plasma lithium concentration compared with rats treated with lithium alone (Table 1).

What does a lack of aldosterone do to blood pressure?

Patients with primary adrenal insufficiency causing low levels of aldosterone may experience low blood pressure, increased potassium levels, and lethargy. Genetic mutations can also affect the production of aldosterone.

Can you eat bananas on spironolactone?

Avoid taking salt substitutes that contain potassium or potassium supplements while taking spironolactone. Try to avoid foods high in potassium (such as avocados, bananas, coconut water, spinach, and sweet potato) because eating these foods may lead to potentially fatal hyperkalemia (high blood potassium levels).